Climate change may be aiding a deadly fungus in infecting humans | Science News for Students

Climate change may be aiding a deadly fungus in infecting humans

The number of cases of fungal infections has increased around the world
Aug 30, 2019 — 6:45 am EST
an illustration of Candida auris fungus

A fungus called Candida auris (illustrated) can cause deadly infections in people.

Dr_Microbe/iStock/Getty Images Plus

Fungal diseases have devastated many animal and plant species. Humans and other mammals, however, have been mostly spared. There may be two reasons for that. Their body temperatures are too warm for most fungi to replicate in. Mammals also have powerful immune systems. But climate change may be bringing new fungal threats to human health.

From 2012 to 2015, versions of a deadly fungus showed up at the same time in Africa, Asia and South America. It’s named Candida auris (Kan-DEE-da OAR-is). All versions are from this same species. But the versions on each continent had a different genetic makeup. So the fungus wasn’t spread by infected travelers, concluded Arturo Casadevall. He is a microbiologist at the Johns Hopkins Bloomberg School of Public Health in Baltimore, Md.

C. auris is a health concern because it can cause deadly infections in people. To infect humans, the fungus had to become more tolerant of warmer temperatures. C. auris may have adapted to the average normal body temperature of humans. That is about 37° Celsius (98.6° Fahrenheit). And climate change may have made this possible, Casadevall and his colleagues now propose.

If true, the researchers write, C. auris “may be the first example of a new fungal disease emerging from climate change” that poses a risk to people. The researchers reported their finding online July 23 in mBio

There have been nearly 700 U.S. cases of C. auris infections since mid-2016. Those cases have occurred in hospitals and other healthcare facilities in 12 states. Some of the patients have died. Cases also have turned up in more than 30 other countries.

a map showing confirmed cases of C. auris in the United States
In the United States, New York, Illinois and New Jersey currently have the highest number of confirmed cases of C. auris.
C. Chang; Data from the CDC

The fungus causes dangerous infections of the blood, brain and heart. An invasive infection can be fatal 30 to 60 percent of the time, studies show. Some infections are resistant to antifungal medicines.

Past work has shown a fungus can grow at warmer temperatures in a lab. “There are millions of fungal species out there,” Casadevall says. “As they adapt to a warmer climate, some of them will then have the capacity to breach our thermal defenses.”

Other fungi are wreaking havoc on many animals and plants. These include frogs, snakes and trees. “A lot of our fellow creatures are being wiped out,” Casadevall says. In general, mammals are “remarkably resistant to invasive fungal diseases.” But bats are mammals, too. And they have been affected by outbreaks of a fungus that causes white-nose syndrome. Bats can get this fungus in part because their body temperature drops during hibernation.

“The fungal kingdom is just so vast,” Casadevall says. If another fungus dangerous to humans evolves, “who knows what it will do to us?”

Power Words

(more about Power Words)

antifungal     Having properties that prevent or limit the growth of fungi.

average     (in science) A term for the arithmetic mean, which is the sum of a group of numbers that is then divided by the size of the group.

bat     A type of winged mammal comprising more than 1,100 separate species — or one in every four known species of mammal.

Candida     A genus of yeasts that are ubiquitous across the globe. More than 20 species have been linked to disease in people and animals.

cell     The smallest structural and functional unit of an organism. Typically too small to see with the unaided eye, it consists of a watery fluid surrounded by a membrane or wall. Depending on their size, animals are made of anywhere from thousands to trillions of cells. Most organisms, such as yeasts, molds, bacteria and some algae, are composed of only one cell.

climate     The weather conditions that typically exist in one area, in general, or over a long period.

climate change     Long-term, significant change in the climate of Earth. It can happen naturally or in response to human activities, including the burning of fossil fuels and clearing of forests.

colleague     Someone who works with another; a co-worker or team member.

continent     (in geology) The huge land masses that sit upon tectonic plates. In modern times, there are six established geologic continents: North America, South America, Eurasia, Africa, Australia and Antarctica. In 2017, scientists also made the case for yet another: Zealandia.

defense     (in biology) A natural protective action taken or chemical response that occurs when a species confront predators or agents that might harm it. (adj. defensive)

environment     The sum of all of the things that exist around some organism or the process and the condition those things create. Environment may refer to the weather and ecosystem in which some animal lives, or, perhaps, the temperature and humidity (or even the placement of things in the vicinity of an item of interest).

evolve     (adj. evolving) To change gradually over generations, or a long period of time. In living organisms, such an evolution usually involves random changes to genes that will then be passed along to an individual’s offspring. These can lead to new traits, such as altered coloration, new susceptibility to disease or protection from it, or different shaped features (such as legs, antennae, toes or internal organs). Nonliving things may also be described as evolving if they change over time. For instance, the miniaturization of computers is sometimes described as these devices evolving to smaller, more complex devices.

fungus     (plural: fungi) One of a group of single- or multiple-celled organisms that reproduce via spores and feed on living or decaying organic matter. Examples include mold, yeasts and mushrooms.

genetic     Having to do with chromosomes, DNA and the genes contained within DNA. The field of science dealing with these biological instructions is known as genetics. People who work in this field are geneticists.

hibernation     A state of inactivity that some animals enter to save energy at certain times of year. Bears and bats, for example, may hibernate through the winter. During this time, the animal does not move very much, and the use of energy by its body slows down. This eliminates the need to feed for months at a time.

immune     (adj.) Having to do with the immunity. (v.) Able to ward off a particular infection. Alternatively, this term can be used to mean an organism shows no impacts from exposure to a particular poison or process. More generally, the term may signal that something cannot be hurt by a particular drug, disease or chemical.

immune system     The collection of cells and their responses that help the body fight off infections and deal with foreign substances that may provoke allergies.

infection     A disease that can spread from one organism to another. It’s usually caused by some type of germ.

invasive     An adjective that refers to something that can invade some environment (such as an invasive species) or alter some environment (such as invasive medical procedures).

mammal     A warm-blooded animal distinguished by the possession of hair or fur, the secretion of milk by females for feeding their young, and (typically) the bearing of live young.

microbiology     The study of microorganisms, principally bacteria, fungi and viruses. Scientists who study microbes and the infections they can cause or ways that they can interact with their environment are known as microbiologists.

online     (n.) On the internet. (adj.) A term for what can be found or accessed on the internet.

outbreak     The sudden emergence of disease in a population of people or animals. The term may also be applied to the sudden emergence of devastating natural phenomena, such as earthquakes or tornadoes.

replicate     (in biology) To copy something. When viruses make new copies of themselves — essentially reproducing — this process is called replication. (in experimentation) To copy an earlier test or experiment — often an earlier test performed by someone else — and get the same general result. Replication depends upon repeating every step of a test, one by one. If a repeated experiment generates the same result as in earlier trials, scientists view this as verifying that the initial result is reliable. If results differ, the initial findings may fall into doubt. Generally, a scientific finding is not fully accepted as being real or true without replication.

risk     The chance or mathematical likelihood that some bad thing might happen. For instance, exposure to radiation poses a risk of cancer. Or the hazard — or peril — itself. (For instance: Among cancer risks that the people faced were radiation and drinking water tainted with arsenic.)

species     A group of similar organisms capable of producing offspring that can survive and reproduce.

syndrome     Two or more symptoms that together characterize a particular disease, disorder or social condition.

thermal     Of or relating to heat. (in meteorology) A relatively small-scale, rising air current produced when Earth’s surface is heated. Thermals are a common source of low level turbulence for aircraft.

white nose syndrome     A fungal disease affecting bats. The fungus, Pseudogymnoascus destructans, lives in caves where bats hibernate through the winter. It causes a white dusting on their noses and on other areas of the body. The fungus causes dehydration and can eat holes through bats’ wings and blood vessels. Eventually, it weakens them, leaving them unable to fly and find food.

Citation

Journal: A. Casadevall et al. On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds. mBio. Published online July 23, 2019. doi: 10.1128/mBio.01397-19.