Could toothpaste give heart disease the brush-off? | Science News for Students

Could toothpaste give heart disease the brush-off?

Use of a special toothpaste seems to help reduce unhealthy inflammation throughout the body
Nov 23, 2016 — 7:00 am EST
Brushing teeth

A girl practices brushing with a new toothpaste that helps remove plaque. An added benefit: It may also cut the risk of heart disease.

Humble Smile Foundation

Bad teeth cause pain and discomfort. But problems with the teeth and gums can have impacts far beyond the mouth. Some studies suggest they can boost a person’s risk of heart disease. Good dental health might help prevent this condition. And a new study tackled the issue with a special toothpaste — one that dyes plaque green.

Plaque is that slimy white stuff that over time builds up on teeth. It’s made from leftover materials from food. And it plays a major role in tooth and gum disease.

Dentists have long suspected that such oral disease might have some role in heart problems, notes Patrick McBride. He’s a cardiologist at the University of Wisconsin School of Medicine and Public Health in Madison. (A cardiologist is a doctor who specializes in treating the heart.) So McBride’s team decided to probe the role of plaque in heart health.

For a new study, McBride’s team recruited 61 men and women between the ages of 19 and 44 for a study on tooth brushing. Half were given normal toothpaste. The other half got the special green-dye toothpaste. (The company that makes the product was not involved in the study.)

All participants were told to follow the same brushing instructions for 60 days. Before and afterward, the researchers measured how much plaque was in each volunteer’s mouth.

green teeth
A toothpaste that dyes plaque green helps people see places that need more brushing. People who used the toothpaste regularly for two months had cleaner teeth — and lower levels of inflammation throughout their entire bodies.
Plaque HD

Regular brushing gets rid of most plaque. Not surprisingly, then, both groups had less plaque on their teeth at the end of the study. But the group using the special toothpaste removed about twice as much plaque as the other group.

The green dye had made it easy for people to see where they needed to do extra brushing. This special toothpaste also softened the plaque. That made it easier to remove. Plus, the green dye could make brushing more interesting. The company that sells the toothpaste has introduced it to groups of children, says McBride. “Kids have fun seeing their teeth turn color and brushing it away,” he explains.

During the study, McBride began using the toothpaste himself just to try it out. He’s looking forward to his next trip to the dentist. He hopes his mouth will be healthier than usual. He quips, “I’m not excited to go to the dentist normally!”

Toothpaste reduced inflammation

It’s cool that the special toothpaste removes lots of plaque. That is, after all, what toothpaste is supposed to do. But a second thing the researchers found might, at first, seem to have little to do with teeth. They measured levels of inflammation in the volunteers’ bodies.


Inflammation is a natural response launched by the body’s immune system. After an injury — such as a scraped knee or sprained ankle — the affected area gets red, hot and swollen. As the term suggests, this inflammation is heating the tissue. That temperature spike can help kill bacteria that might cause an infection.

Inflammation also can occur deep within the body. If someone eats unhealthy foods or doesn’t exercise, fat deposits may build up inside the body’s arteries. (Coincidentally, those deposits are also called plaque — but they’re a different kind of plaque than what builds up on teeth.) These arteries are blood vessels that carry blood away from the heart. To the body, those fat deposits are unwanted intruders. So the immune system responds with inflammation. And it doesn’t focus its inflammatory assault just on the arteries. It mounts this heated immune response throughout the entire body.

And that’s not healthy. The combination of fatty arteries and the inflammation they foster can greatly boost a person’s risk of a heart attack or stroke.

Doctors use a blood test to assess that whole-body inflammation. The test measures the amount of a substance called C-reactive protein (CRP). As inflammation increases in the body, more and more of this protein travels through the bloodstream. As inflammation decreases, so do levels of CRP.

In the initial study, some volunteers had very low levels of CRP before the toothbrushing phase began. It would be impossible for their levels to fall further. A few others had very high levels. This suggested a possible injury or unhealthy condition. So the researchers excluded these two groups of people from a second part of their study.

That left 38 people. Among those people who used the special toothpaste, levels of C-reactive protein in their blood fell by 29 percent. Meanwhile, CRP levels actually climbed in the people who had brushed with the regular toothpaste.

That such a large drop in CRP could occur over just two months “was a surprise to me,” says McBride. He’s very enthusiastic about the results. His group described its findings online October 19 in the American Journal of Medicine.

The new data do not explain why brushing with the special toothpaste reduced inflammation. In fact, that remains unknown. But dentists do know that slimy, plaque-covered teeth lead to gums that are red and sore — or inflamed. Perhaps this oral inflammation boosts inflammation throughout the rest of the body. “[The mouth] is just one part of the body, not a separate place,” notes Susanna Paju. “In the body, everything can have an effect on anything.”

Paju is a dentist and researcher. She works at the University of Helsinki in Finland and was not involved in the new study. The new findings are encouraging, she says. Paju hopes they will encourage people to take better care of their teeth. If they do, she says, these people might experience fewer problems with their teeth. What’s more, she adds, they may also keep their whole bodies healthier in the long run.

Toothpaste for the heart

The new toothpaste reduced blood levels of CRP in this small study. A high level of CRP makes heart attacks and strokes more likely. Still, the researchers caution that it’s too early to say whether brushing with the toothpaste used in his study actually can help prevent a heart attack. McBride says his team will need to do more research.

Paju agrees: “I would not dare to say yet that a toothpaste can save your life.”

McBride’s group plans to recruit between 3,000 and 6,000 people for a big follow-up study. Again, half will use the new toothpaste. The rest will brush with a conventional toothpaste. This time, though, the researchers will track heart attacks and strokes in both groups for two to three years.

If the toothpaste actually works to lower the risk of heart disease, that would be an important finding. Heart attacks and strokes are the leading cause of death in the United States today. They will likely continue to plague future generations as well. Young people today are heavier and less active than previous generations. So they are at a high risk for developing heart disease. Toothpaste is something everyone should use and is relatively cheap. Any heart benefits would be an amazing bonus.

No matter what the larger follow-up study finds, the best way to keep the heart healthy will remain the same. Eat lots of fruits and vegetables, exercise and don’t smoke. Toothpaste, no matter how amazing, can never take the place of an active, healthy lifestyle.

Power Words

(for more about Power Words, click here)

bacterial     Having to do with bacteria, single-celled organisms. These dwell nearly everywhere on Earth, from the bottom of the sea to inside animals.

C-reactive protein     This is one of the proteins that circulates around the body in the blood's plasma. It is considered an "acute phase" protein as its amount will rise when the body considers itself under some type of inflammatory threat. As such, doctors may use high levels of this protein as a sign of an excessive (unhealthy) amount of inflammation. One trigger for this protein: the unhealthy buildup of fatty deposits in the blood system.

fat     A natural oily or greasy substance occurring in animal bodies, especially when deposited as a layer under the skin or around certain organs. Fat’s primary role is as an energy reserve. Fat is also a vital nutrient, though it can be harmful to one’s health if consumed in excess amounts.

generation     A group of individuals born about the same time or that are regarded as a single group. Your parents belong to one generation of your family, for example, and your grandparents to another. Similarly, you and everyone within a few years of your age across the planet are referred to as belonging to a particular generation of humans. The term also is sometimes extended to year classes or types of inanimate objects, such as electronics or automobiles.

heart attack     Permanent damage to the heart muscle that occurs when one or more regions of it become starved of oxygen, usually due to a temporary blockage in blood flow.

immune     Able to ward off a particular infection. Alternatively, this term can mean to show no impacts from a particular poison or process. More generally, the term may signal that something cannot be hurt by a particular drug, disease or chemical.

immune system     The collection of cells and their responses that help the body fight off infections and deal with foreign substances that may provoke allergies.

infection     A disease that can spread from one organism to another. It’s usually caused by some sort of germ.

inflammation     The body’s response to cellular injury and obesity; it often involves swelling, redness, heat and pain. It is also an underlying feature responsible for the development and aggravation of many diseases, especially heart disease and diabetes.

oral     An adjective that refers to things in or affecting the mouth.

plaque     (in oral health) A biofilm, or community of bacterial species, that grows on teeth and other surfaces in the mouth.

recruit     (in research) New member of a group or human trial, or to enroll a new member into a research trial. Some may receive money or other compensation for their participation, particularly if they enter the trial healthy.

risk     The chance or mathematical likelihood that some bad thing might happen. For instance, exposure to radiation poses a risk of cancer. Or the hazard — or peril — itself. Among cancer risks that the people faced were radiation and drinking water tainted with arsenic.

side effects     Unintended problems or harm caused by a procedure or treatment.

stroke     (in biology and medicine) A condition where blood stops flowing to part of the brain or leaks in the brain.

tissue     Any of the distinct types of material, comprised of cells, which make up animals, plants or fungi. Cells within a tissue work as a unit to perform a particular function in living organisms. Different organs of the human body, for instance, often are made from many different types of tissues. And brain tissue will be very different from bone or heart tissue.


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Journal: K. Fasula et al. Randomized trial of plaque identifying toothpaste: Dental plaque and inflammation. The American Journal of Medicine. Published online October 19, 2016. doi: 10.1016/j.amjmed.2016.09.003.

Further Reading

Learn more about inflammation and heart disease from the American Heart Association.