Stuttering: Blood flow in the brain may play a role | Science News for Students

Stuttering: Blood flow in the brain may play a role

It is diminished in the language region known as Broca’s area
Feb 1, 2017 — 7:10 am EST
child stutter

Stuttering is a disorder that causes halting speech.


People once thought stuttering was just a symptom of being overly nervous. No more. Many people inherit their condition, and a new study points to blood flow as a possible contributor.

Stuttering causes halting speech. Myths about its cause and possible cures abound. People once believed tickling a baby too much could lead to stuttering. Others blamed it on having left a baby out in the rain. Some tried to cure the disorder by holding nutmeg under a stutterer’s nose or slapping the victim with a shoe. Some people still treat stutterers as if they’re unintelligent, or overly nervous. Even scientists have been stumped by what’s behind this language disorder.

Brain imaging, however, may just have filled in an important piece of the stuttering puzzle. Jay Desai is a clinical neurologist. He works at the Children’s Hospital of Los Angeles in California. There, he uses a brain-scanning technique called magnetic resonance imaging, or MRI, to observe blood flow in the brain. In a new study, he compared MRI scans of 26 stutterers (both adults and children) to those from 36 non-stutterers. No one spoke or moved while their brain scan was underway. That let Desai look for differences in their brains while “resting.”

Broca’s area
Researchers have just linked stuttering to reduced blood flow in Broca’s area, the region shown in red.
"BodyParts3D, © The Database Center for Life Science/Wikimedia (CC BY-SA-2.1)

These images showed that less blood flowed to the Broca’s area in the stutterers. Near the front of the brain, this region is involved in language and speech production. Blood flow to the Broca’s area was lowest in persons with the most extreme stutters.

Findings by Desai’s team will appear in an upcoming issue of Human Brain Mapping.

Psychiatrists once thought stuttering was due to stress or traumatic experiences. Studies instead have shown that inherited traits can play a role.

“Although we don’t have an answer for what gene may be responsible for stuttering, we now know that there’s a biological basis for it,” Desai says. Does low blood flow mean stutterers have less brain activity in Broca’s area? “We’re still not sure,” he says.

What he does know: Although 5 percent of children develop stutters when they’re learning to talk, three-quarters of them eventually outgrow it.

The new study does not explain what causes stuttering. But it may one day help researchers find a cure. “Is there a way to increase blood flow to this area, and will that work to treat stuttering?” Desai asks. That could prove a useful avenue of research.

Power Words

(for more about Power Words, click here)

brain scan     The use of an imaging technology, typically using X rays or a magnetic resonance imaging (or MRI) machine, to view structures inside the brain. With MRI technology — especially the type known as functional MRI (or fMRI) — the activity of different brain regions can be viewed during an event, such as viewing pictures, computing sums or listening to music.

clinical     (in medicine) A term that refers to diagnoses, treatments or experiments involving people.

cure     (in food science) To treat foods so that they resist spoilage and food-poisoning microbes. Types of processes used for curing foods include pickling, smoking, drying and treating with chemicals such as nitrates (or nitrates) and sulfates.

disorder     (in medicine) A condition where the body does not work appropriately, leading to what might be viewed as an illness. This term can sometimes be used interchangeably with disease.

gene     (adj. genetic) A segment of DNA that codes, or holds instructions, for producing a protein. Offspring inherit genes from their parents. Genes influence how an organism looks and behaves.

magnetic resonance imaging     (MRI) An imaging technique to visualize soft, internal organs, like the brain, muscles, heart and cancerous tumors. MRI uses strong magnetic fields to record the activity of individual atoms.

stress     (in biology) A factor, such as unusual temperatures, moisture or pollution, that affects the health of a species or ecosystem. (in psychology) A mental, physical, emotional, or behavioral reaction to an event or circumstance, or stressor, that disturbs a person or animal’s usual state of being or places increased demands on a person or animal; psychological stress can be either positive or negative.

symptom     A physical or mental indicator generally regarded to be characteristic of a disease. Sometimes a single symptom — especially a general one, such as fever or pain — can be a sign of any of many different types of injury or disease.

trait     A characteristic feature of something. (in genetics) A quality or characteristic that can be inherited.


Journal: Jay Desai et al. “Reduced perfusion in Broca’s area in developmental stuttering.” Human Brain Mapping. Published early online December 30, 2016. DOI: 10.1002/hbm.23487.