LOS ANGELES, Calif. — Seizures can be debilitating. They can strike with little or no warning. And if one comes on when someone is driving or engaged in some other type of physical activity, they might also prove dangerous. But research projects by two teens now suggest that a simple device that monitors brainwaves might warn when a seizure is on the way. And that may save lives, the young researchers say.
Epilepsy is believed to stem from overactive neurons, or brain cells that conduct electricity. This brain disorder often triggers seizures, which are uncontrolled “electrical storms” in the brain. Each patient’s epilepsy can be somewhat unique. In some people, those electrical storms occur throughout the brain. In others, the storms are more localized. That is, they take place in one particular part of the brain. For many people, medicine can partially or totally eliminate the risk of seizures.
When seizures occur, they may be mild. Other times, they can strike severely and without warning, lasting several minutes or more. People with epilepsy often take great care to avoid activities that could pose risks if a seizure occurred. (And in many states, epilepsy may make it hard for people to get a driver’s license.)
Neha Hulkund is an 11th-grader at Tesla STEM High School in Redmond, Wash. (STEM stands for Science, Technology, Engineering and Mathematics.) This 17-year-old appreciates how dangerous seizures can be. A family member had one while riding a bike down a street in India crowded with traffic. Her relative wasn’t seriously injured. But if a seizure caused someone to fall in front of moving cars, and the brain storm temporarily incapacitated them, the situation could have been dire, she notes.
This got Neha to thinking: Is there some way to tell when a seizure is coming? The teen decided to analyze brainwaves that had been recorded in epileptic patients as part of a 2008 study at Boston Children’s Hospital. Why choose those? They are available online for free. So anyone can analyze them, she notes.
Her preliminary work appears successful. Although patients in the study were children, epilepsy can last a lifetime. So her analysis might be useful for adult patients too.
Machine learning scouted for patterns
Neha focused on brainwaves recorded in five patients. Together, they had suffered 20 seizures as doctors had been scanning their brain activity. Some scans had lasted an hour or more, Neha notes. Throughout, patients had worn a stretchy cap that included a lot of electrodes. More than a dozen of those sensors picked up electrical signals from inside the patient’s skull. Wires carried those signals to a recorder.
In the data set Neha used, doctors had marked the beginning of each seizure. She then trained a computer to look for brain-activity patterns before each seizure that might signal an upcoming brain storm. She used a technique called machine learning. Computers that employ this technique are “taught” to scout for patterns in data (rather than being specifically programmed to do so). Here, Neha taught it to analyze brainwaves recorded just before each seizure began.
Sometimes, Neha analyzed only 30 seconds’ worth of pre-seizure data. Other times, the recordings were up to 5 minutes long.
Neha’s method of scouting brainwave patterns would appear to predict impending seizures 3 minutes before they occurred. And they did that with 96 percent accuracy. A 5-minute warning based on her technique would be less accurate, at around 87 percent. But if a 30-second warning is all that’s desired, the method would be more than 99 percent accurate, her data suggest.
However, the teen notes, the more warning patients can get of an impending seizure, the better the chance they can safely stop what they’re doing.
Such warnings could come from a small electronic device that a patient might wear, the teen explains. That mini-computer would get its data from sensors in a cap or other headgear worn by the patient. It’s possible the data could be transmitted wirelessly. So, the monitoring system wouldn’t have to be obvious to others.
Neha showcased her research last week, here, at the Intel International Science and Engineering Fair. ISEF was created by Society for Science & the Public and is sponsored by Intel. The competition lets students from around the world show off their winning science fair projects. (The Society also publishes Science News for Students.) This year, nearly 1,800 high school students from more than 75 countries competed for big prizes and the ability to display their research findings. Neha’s project earned her two awards and a cool $1,500.
Related project also suggests promise
Another ISEF finalist conducted similar research this year. She even used data from the same study at Boston Children’s Hospital. Maanasi Garg attends Stanton College Preparatory School in Jacksonville, Fla. In her analyses, this 11th-grader looked at brainwave patterns from eight patients. The teen used statistics to compare patterns recorded before and during seizures with patterns during normal brain activity. Unlike Neha, Maanasi only looked at brainwave patterns recorded in the 30 seconds leading up to a seizure.
In particular, Maanasi looked at brainwaves of certain frequencies. For seven of the eight patients she studied, brainwaves cycling between 70 and 100 times per second contributed the most electrical power during seizures. And for six of those seven patients, brainwaves at those frequencies showed a distinct pattern that indicated a seizure was on its way.
So, like Neha, Maanasi found that early warnings of a seizure might be possible for many patients. She also suggests that seizure-prone patients could wear a sensor-laden cap and an electronic device to monitor their brainwaves. “Thirty seconds would likely be enough warning to stop any dangerous activity,” she notes.
biology The study of living things. The scientists who study them are known as biologists.
brainwave An electrical signal produced through the coordinated activity of billions of neurons in the brain of an animal. When charted, the signal typically looks wavy or spiky.
cell The smallest structural and functional unit of an organism. Typically too small to see with the unaided eye, it consists of a watery fluid surrounded by a membrane or wall. Depending on their size, animals are made of anywhere from thousands to trillions of cells. Most organisms, such as yeasts, molds, bacteria and some algae, are composed of only one cell.
computational biology A field in which scientists use mathematics and computer programs to better understand living things.
data Facts and/or statistics collected together for analysis but not necessarily organized in a way that gives them meaning. For digital information (the type stored by computers), those data typically are numbers stored in a binary code, portrayed as strings of zeros and ones.
dire An adjective that means grave, or hard to survive.
disorder (in medicine) A condition where the body does not work appropriately, leading to what might be viewed as an illness. This term can sometimes be used interchangeably with disease.
electricity A flow of charge, usually from the movement of negatively charged particles, called electrons.
electrode A device that conducts electricity and is used to make contact with non-metal part of an electrical circuit, or that contacts something through which an electrical signal moves. (in electronics) Part of a semiconductor device (such as a transistor) that either releases or collects electrons or holes, or that can control their movement.
engineering The field of research that uses math and science to solve practical problems.
epilepsy A neurological disorder characterized by seizures.
Intel International Science and Engineering Fair (Intel ISEF) Initially launched in 1950, this competition is one of three created (and still run) by the Society for Science & the Public. Each year now, approximately 1,800 high school students from more than 75 countries, regions, and territories are awarded the opportunity to showcase their independent research at Intel ISEF and compete for an average of $4 million in prizes.
machine learning A technique in computer science that allows computers to learn from examples or experience. Machine learning is the basis of some forms of artificial intelligence (AI).
neuron An impulse-conducting cell. Such cells are found in the brain, spinal column and nervous system.
preliminary An early step or stage that precedes something more important.
risk The chance or mathematical likelihood that some bad thing might happen. For instance, exposure to radiation poses a risk of cancer. Or the hazard — or peril — itself. (For instance: Among cancer risks that the people faced were radiation and drinking water tainted with arsenic.)
seizure A sudden surge of electrical activity within the brain. Seizures are often a symptom of epilepsy and may cause dramatic spasming of muscles.
sensor A device that picks up information on physical or chemical conditions — such as temperature, barometric pressure, salinity, humidity, pH, light intensity or radiation — and stores or broadcasts that information. Scientists and engineers often rely on sensors to inform them of conditions that may change over time or that exist far from where a researcher can measure them directly. (in biology) The structure that an organism uses to sense attributes of its environment, such as heat, winds, chemicals, moisture, trauma or an attack by predators.
skull The skeleton of a person’s or animal’s head.
statistics The practice or science of collecting and analyzing numerical data in large quantities and interpreting their meaning. Much of this work involves reducing errors that might be attributable to random variation. A professional who works in this field is called a statistician.
unique Something that is unlike anything else; the only one of its kind.
Meeting: N. Hulkund. The application of machine learning algorithms on EEG data to predict and detect epileptic seizures. May 15, 2017. Los Angeles, Calif.
Meeting: M. Garg. Seizure prediction using spectral density analysis on pediatric EEGs. May 15, 2017. Los Angeles, Calif.
More about epilepsy:
National Institute of Neurological Disorders and Stroke Epilepsy information page.
National Institutes of Health epilepsy fact sheet.
U.S. National Library of Medicine seizures homepage.
More about Intel ISEF:
“Welcome to Intel ISEF 2017.” May 16, 2017.
“Intel ISEF 2017 begins.” May 15, 2017.